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Impaired Sensitivity to Thyroid Hormone (Thyroid Hormone Resistance): A Cause of Fibromyalgia, Chronic Fatigue, ME, Coeliac Disease, MS, Heart Disease, Depression and Many Other Conditions

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Impaired Sensitivity to Thyroid Hormone (ISTH) is a term which describes a number of genetic defects which interfere with the working of thyroid hormones and cause symptoms similar to hypothyroidism. It is a recognised medical condition although many doctors have not heard of it. Some doctors may however be aware of it under another name such as Thyroid Hormone Resistance Impaired Sensitivity to Thyroid Hormone (ISTH) is a term which describes a number of genetic defects which interfere with the working of thyroid hormones and cause symptoms similar to hypothyroidism. It is a recognised medical condition although many doctors have not heard of it. Some doctors may however be aware of it under another name such as Thyroid Hormone Resistance or Resistance to Thyroid Hormone. Those doctors who are aware of the condition view it as extremely rare (1 in 50,000) and associated with severe disability. It is therefore not something to consider as a possibility when they see a patient with hypothyroid symptoms but normal thyroid blood tests. They are instead likely to give a diagnosis of fibromyalgia, Chronic Fatigue Syndrome, ME or depression. The UK National Health Service (NHS) website states that the cause of fibromyalgia is unknown and “It's also suggested that some people are more likely to develop fibromyalgia because of genes inherited from their parents.” Impaired Sensitivity to Thyroid Hormone is genetic and is the likely genetic cause of fibromyalgia. Both fibromyalgia and Chronic Fatigue Syndrome can cause long term illness and disability. Currently the main treatments for both conditions are antidepressants and painkillers. It is likely that ISTH is not rare and may even be common as indicated by estimates which suggest that nearly 1 in 20 people may be affected by fibromyalgia to some degree. ISTH is a common and treatable thyroid condition and it is essential that the medical profession become aware of it, so that sufferers can receive appropriate treatment and have their health restored. This book brings together information from many sources and seeks to present it in a concise, easy to read form suitable for people with no medical knowledge. The key information in the book is from published medical research and official medical websites and references to the sources have been included at the end of each chapter to allow verification.


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Impaired Sensitivity to Thyroid Hormone (ISTH) is a term which describes a number of genetic defects which interfere with the working of thyroid hormones and cause symptoms similar to hypothyroidism. It is a recognised medical condition although many doctors have not heard of it. Some doctors may however be aware of it under another name such as Thyroid Hormone Resistance Impaired Sensitivity to Thyroid Hormone (ISTH) is a term which describes a number of genetic defects which interfere with the working of thyroid hormones and cause symptoms similar to hypothyroidism. It is a recognised medical condition although many doctors have not heard of it. Some doctors may however be aware of it under another name such as Thyroid Hormone Resistance or Resistance to Thyroid Hormone. Those doctors who are aware of the condition view it as extremely rare (1 in 50,000) and associated with severe disability. It is therefore not something to consider as a possibility when they see a patient with hypothyroid symptoms but normal thyroid blood tests. They are instead likely to give a diagnosis of fibromyalgia, Chronic Fatigue Syndrome, ME or depression. The UK National Health Service (NHS) website states that the cause of fibromyalgia is unknown and “It's also suggested that some people are more likely to develop fibromyalgia because of genes inherited from their parents.” Impaired Sensitivity to Thyroid Hormone is genetic and is the likely genetic cause of fibromyalgia. Both fibromyalgia and Chronic Fatigue Syndrome can cause long term illness and disability. Currently the main treatments for both conditions are antidepressants and painkillers. It is likely that ISTH is not rare and may even be common as indicated by estimates which suggest that nearly 1 in 20 people may be affected by fibromyalgia to some degree. ISTH is a common and treatable thyroid condition and it is essential that the medical profession become aware of it, so that sufferers can receive appropriate treatment and have their health restored. This book brings together information from many sources and seeks to present it in a concise, easy to read form suitable for people with no medical knowledge. The key information in the book is from published medical research and official medical websites and references to the sources have been included at the end of each chapter to allow verification.

23 review for Impaired Sensitivity to Thyroid Hormone (Thyroid Hormone Resistance): A Cause of Fibromyalgia, Chronic Fatigue, ME, Coeliac Disease, MS, Heart Disease, Depression and Many Other Conditions

  1. 4 out of 5

    Elizabeth H Dole

    Useful & New Info for Me Fascinating to learn about a different cause of hypothyroidism. It was well-explained, and contained excellent references that I intend to research. Author provides one with a good understanding of the genetic component related to this alternative thyroid issue.

  2. 4 out of 5

    Daniella Stewart

    Essential information Although I gave this book 5 stars, I would have liked more in depth information about T3 ranges and the basal body temperature, to allow me to discuss greater detail with my doctor. Overall very good though and everyone should read it. Great that it is offered free on Kindle.

  3. 5 out of 5

    Elizabeth Mackay

    Enlightening with links to research backing up info I have already recommended this book to several people. 'Chronic fatigue syndrome did not exist until the 1980s when doctors stopped looking at symptoms to treat hypothyroidism and relied on blood tests'. Enlightening with links to research backing up info I have already recommended this book to several people. 'Chronic fatigue syndrome did not exist until the 1980s when doctors stopped looking at symptoms to treat hypothyroidism and relied on blood tests'.

  4. 5 out of 5

    Aneliya Petrunova

    This is a really useful little book, with a lot of helpful information on recognizing and treating impaired sensitivity to thyroid hormone. Dr. Hamilton discusses the symptoms ISTH produces and the numerous conditions it can in turn lead to. He also discusses treatment with T3 only (even though he does mention that T4 canbe helpful in many people), providing instructions on dosage and busting some myths surrounding T3. I would recommend this book to anyone with symptoms of hypiothyroidism who is This is a really useful little book, with a lot of helpful information on recognizing and treating impaired sensitivity to thyroid hormone. Dr. Hamilton discusses the symptoms ISTH produces and the numerous conditions it can in turn lead to. He also discusses treatment with T3 only (even though he does mention that T4 canbe helpful in many people), providing instructions on dosage and busting some myths surrounding T3. I would recommend this book to anyone with symptoms of hypiothyroidism who isn't getting the treatment they need and is looking for answers.

  5. 4 out of 5

    Diane Hetfield

  6. 5 out of 5

    Monica M Kuchera

  7. 5 out of 5

    sylvia lowe

  8. 5 out of 5

    Pam Gunn

  9. 5 out of 5

    Julie Batson

  10. 5 out of 5

    Danielle

  11. 5 out of 5

    alan berkowitz

  12. 4 out of 5

    Kellie Redondo

  13. 5 out of 5

    Stacy

  14. 5 out of 5

    Tatyana Valda

  15. 4 out of 5

    Vasyl

  16. 4 out of 5

    CSchlapo

  17. 5 out of 5

    Andre

  18. 4 out of 5

    Nathan

  19. 5 out of 5

    S A

  20. 4 out of 5

    Jia Lu

  21. 5 out of 5

    Andy Babkes

  22. 4 out of 5

    Jenny

  23. 4 out of 5

    Kameloth

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