This book recounts the Ebola Virus Outbreak of 2014-2015 by merging clinical and diagnostic issues with behavioral and political factors. Lessons learned are intended to help future respondents by improving coordination and collaboration. The book begins with a report of an earlier prediction of an impending outbreak based on serological evidence from a decade earlier. Thi This book recounts the Ebola Virus Outbreak of 2014-2015 by merging clinical and diagnostic issues with behavioral and political factors. Lessons learned are intended to help future respondents by improving coordination and collaboration. The book begins with a report of an earlier prediction of an impending outbreak based on serological evidence from a decade earlier. This warning was ignored. As a result, early cases of Ebola and efforts to control the epidemic were hindered by old approaches, and human behavior, facilitating the spread of the virus, worsening the outbreak. This is a case study of failures and successes highlighted by the struggle to halt this devastating epidemic.